There is considerable evidence, primarily from epidemiologic studies, demonstrating an association between low levels of HDL and an increased risk of coronary artery disease. Recently, interest has focused on the role of HDL as an anti risk factor. The HDL isolated in the density range 1.603 to 1.21 are, in fact, a heterogenous group of macromolecules. HDL cholesterol has been estimated as an index of HDL level in clinical laboratory. But, a reduction of HDL cholesterol could be secondary to an increase in triglyceride, therefore apoprotein A-I, indicating that is a functional unit of HDL, may correlate better with coronary disease risk than HDL cholesterol.
Serum lipids, lipoprotein fraction, HDL cholesterol and apoprotein A-I were measured in 39 patients with ischemic heart disease, in 27 patients with uncomplicated, hypertriglycemic hypertension and in 19 patients with uncomplicated, hypertriglycemic NIDDM.
The results obtained were as follows:
1) The mean levels of serum HDL cholesterol, apoprotein A-I and molar ratio of HDL cholesterol/apoprotein A-I in ischemic heart disease patients were 31.3 ± 9.8 mg/dl, 122.7 ± 23.6 mg/dl and 18.2 ± 8.1.
The levels of serum HDL cholesterol, apoprotein A-I and molar ratio of HDL cholesterol/apoprotein A-I were significantly lower in ischemic heart disease patients than in normal control group.
2) The mean level of serum HDL cholesterol and molar ratio of HDL cholesterol/apoprotein A-I in uncomplicated, hypertriglycemic NIDDM patients were 33.7 ± 5.4 mg/dl, 16.5 ± 6.8. The level of HDL cholesterol and molar ratio of HDL cholesterol/apoprotein A-I were significantly lower in hypertriglycemic NIDDM patients without complication than in normal control group. But the level of serum apoprotein A-I was 149.7 ± 11.2 mg/dl, and than no signifi-cant difference was found between hyperglycemic NIDDM patients without complica-tion and normal control group.
3) The mean level of HDL cholesterol and molar ratio of HDL cholesterol/apopro-tein A-I in uncomplicated, hypertriglycemic hypertensive patients were 36.2 ± 8.5 mg/dl, 17.8 ± 5.4.
The level of HDL cholesterol and molar ratio of HDL cholesterol/apoprotein A-I were significantly lower in hypertriglycemic hypertensive patients without complica-tion than in normal control group. But the level of serum apoprotein A-I was 154.7 ± 25.0 mg/dl, and than no significant difference was found between hyper-triglycemic hypertensive patients without complication and normal control group.
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